An animal model to study health effects during continuous low-dose exposure to the nerve agent VX.

@article{Rocksn2008AnAM,
  title={An animal model to study health effects during continuous low-dose exposure to the nerve agent VX.},
  author={David Rocks{\'e}n and Daniel Elfsmark and Victoria Heldestad and Karin Wallgren and Gudrun Cassel and Ann G{\"o}ransson Nyberg},
  journal={Toxicology},
  year={2008},
  volume={250 1},
  pages={32-8}
}
In the present study, we have developed an animal model to study long-term health effects of continuous exposure of toxic chemical agents, in awake, freely moving rats. The aim was to evaluate the effect of low-dose exposure of the nerve agent VX, and to find specific biomarkers for intoxication. To exclude the influence of stress, we used an implanted radio-telemetric device for online registration of physiological parameters, and an osmotic pump, implanted subcutaneously, for continuous… CONTINUE READING