An animal model to evaluate the function and regulation of the adaptively evolving stress protein SEP53 in oesophageal bile damage responses

@article{Nelson2008AnAM,
  title={An animal model to evaluate the function and regulation of the adaptively evolving stress protein SEP53 in oesophageal bile damage responses},
  author={Lenny Nelson and S Anderson and Alan L. Archibald and Susan Rhind and Zen Huat Lu and Alison Condie and Neal McIntyre and Jill Thompson and Rudolf Nenutil and Borivoj Vojtesek and Christopher Bruce Alexander Whitelaw and Tom J. Little and Ted R. Hupp},
  journal={Cell Stress and Chaperones},
  year={2008},
  volume={13},
  pages={375-385}
}
Squamous epithelium in mammals has evolved an atypical stress response involving down-regulation of the classic HSP70 protein and induction of sets of proteins including one named SEP53. This atypical stress response might be due to the unusual environmental pressures placed on squamous tissue. In fact, SEP53 plays a role as an anti-apoptotic factor in response to DNA damage induced by deoxycholic acid stresses implicated in oesophageal reflux disease. SEP53 also has a genetic signature… CONTINUE READING

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