An animal model of panic vulnerability with chronic disinhibition of the dorsomedial/perifornical hypothalamus.

@article{Johnson2012AnAM,
  title={An animal model of panic vulnerability with chronic disinhibition of the dorsomedial/perifornical hypothalamus.},
  author={Philip L F Johnson and Anantha S Shekhar},
  journal={Physiology & behavior},
  year={2012},
  volume={107 5},
  pages={686-98}
}
Panic disorder (PD) is a severe anxiety disorder characterized by susceptibility to induction of panic attacks by subthreshold interoceptive stimuli such as sodium lactate infusions or hypercapnia induction. Here we review a model of panic vulnerability in rats involving chronic inhibition of GABAergic tone in the dorsomedial/perifornical hypothalamic (DMH/PeF) region that produces enhanced anxiety and freezing responses in fearful situations, as well as a vulnerability to displaying acute… CONTINUE READING