An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice

@article{Ambati2003AnAM,
  title={An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice},
  author={Jayakrishna Ambati and Akshay Anand and Stefan Fernandez and Eiji Sakurai and Bert C. Lynn and William A. Kuziel and Barrett J. Rollins and Balamurali Krishna Ambati},
  journal={Nature Medicine},
  year={2003},
  volume={9},
  pages={1390-1397}
}
The study and treatment of age-related macular degeneration (AMD), a leading cause of blindness, has been hampered by a lack of animal models. Here we report that mice deficient either in monocyte chemoattractant protein-1 (Ccl-2; also known as MCP-1) or its cognate C-C chemokine receptor-2 (Ccr-2) develop cardinal features of AMD, including accumulation of lipofuscin in and drusen beneath the retinal pigmented epithelium (RPE), photoreceptor atrophy and choroidal neovascularization (CNV… CONTINUE READING
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