An animal model mimicking pedunculopontine nucleus cholinergic degeneration in Parkinson’s disease


A rostral brainstem structure, the pedunculopontine nucleus (PPN), is severely affected by Parkinson’s disease (PD) pathology and is regarded a promising target for therapeutic deep-brain stimulation (DBS). However, understanding the PPN’s role in PD and assessing the potential of DBS are hampered by the lack of a suitable model of PPN degeneration. Rats… (More)
DOI: 10.1007/s00429-013-0669-5