An animal model for adenosine-induced bronchoconstriction.

@article{Pauwels1987AnAM,
  title={An animal model for adenosine-induced bronchoconstriction.},
  author={R. Pauwels and M. E. van der Straeten},
  journal={The American review of respiratory disease},
  year={1987},
  volume={136 2},
  pages={
          374-8
        }
}
The inhalation of adenosine is known to cause bronchoconstriction in asthmatic patients. A thorough study of the possible role of this purine nucleoside in the pathogenesis of asthma has been hampered by the lack of a suitable animal model. We have studied the bronchial effects of adenosine in an in vivo rat model. The intravenous injection of 0.1 to 10 micromoles/kg body weight of adenosine causes in BDE-rats an increase in lung resistance and decrease in dynamic compliance. Study of the… Expand
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