An angiotensin II type 1 receptor activation switch patch revealed through evolutionary trace analysis.

Abstract

Seven transmembrane (7TM) or G protein-coupled receptors constitute a large superfamily of cell surface receptors sharing a structural motif of seven transmembrane spanning alpha helices. Their activation mechanism most likely involves concerted movements of the transmembrane helices, but remains to be completely resolved. Evolutionary Trace (ET) analysis… (More)
DOI: 10.1016/j.bcp.2010.03.006

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