An angiogenic role for the human peptide antibiotic LL-37/hCAP-18.

  title={An angiogenic role for the human peptide antibiotic LL-37/hCAP-18.},
  author={R. Koczulla and G. von Degenfeld and C. Kupatt and F. Kroetz and S. Zahler and T. Gloe and Katja Issbr{\"u}cker and P. Unterberger and M. Zaiou and C. Lebherz and A. Karl and P. Raake and A. Pfosser and P. Boekstegers and U. Welsch and P. Hiemstra and C. Vogelmeier and R. Gallo and M. Clauss and R. Bals},
  journal={The Journal of clinical investigation},
  volume={111 11},
  • R. Koczulla, G. von Degenfeld, +17 authors R. Bals
  • Published 2003
  • Biology, Medicine
  • The Journal of clinical investigation
  • Antimicrobial peptides are effector molecules of the innate immune system and contribute to host defense and regulation of inflammation. The human cathelicidin antimicrobial peptide LL-37/hCAP-18 is expressed in leukocytes and epithelial cells and secreted into wound and airway surface fluid. Here we show that LL-37 induces angiogenesis mediated by formyl peptide receptor-like 1 expressed on endothelial cells. Application of LL-37 resulted in neovascularization in the chorioallantoic membrane… CONTINUE READING
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    Endogenous antimicrobial peptides and skin infections in atopic dermatitis.
    • 1,649
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    • 1,144
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    Mechanisms of angiogenesis and arteriogenesis
    • 3,814
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    Epithelial antimicrobial peptides in host defense against infection
    • 456
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