An angiogenic role for the human peptide antibiotic LL-37/hCAP-18.

  title={An angiogenic role for the human peptide antibiotic LL-37/hCAP-18.},
  author={Rembert Andreas Koczulla and Georges von Degenfeld and Christian Kupatt and Florian Kroetz and Stefan Zahler and Torsten Gloe and Katja Issbr{\"u}cker and Pia Unterberger and Mohamed Zaiou and Corinna Lebherz and Alexander Karl and Philip W.J. Raake and Achim Pfosser and Peter Boekstegers and Ulrich Welsch and Pieter S Hiemstra and Claus F Vogelmeier and Richard L Gallo and Matthias Clauss and Robert Bals},
  journal={The Journal of clinical investigation},
  volume={111 11},
Antimicrobial peptides are effector molecules of the innate immune system and contribute to host defense and regulation of inflammation. The human cathelicidin antimicrobial peptide LL-37/hCAP-18 is expressed in leukocytes and epithelial cells and secreted into wound and airway surface fluid. Here we show that LL-37 induces angiogenesis mediated by formyl peptide receptor-like 1 expressed on endothelial cells. Application of LL-37 resulted in neovascularization in the chorioallantoic membrane… CONTINUE READING
Highly Influential
This paper has highly influenced 10 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
283 Citations
37 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 283 extracted citations


Publications referenced by this paper.
Showing 1-10 of 37 references

Similar Papers

Loading similar papers…