An angel with Down syndrome in a sixteenth century Flemish Nativity painting

@article{Levitas2003AnAW,
  title={An angel with Down syndrome in a sixteenth century Flemish Nativity painting},
  author={Andrew S. Levitas and Cheryl S. Reid},
  journal={American Journal of Medical Genetics Part A},
  year={2003},
  volume={116A}
}
  • A. Levitas, C. Reid
  • Published 1 February 2003
  • History, Medicine
  • American Journal of Medical Genetics Part A
Artistic representation of malformation syndromes has been of ongoing interest, often as a point of departure for discussion of medical history. We have identified a 16th‐century Flemish Nativity painting in which one angelic figure appears distinctly different from other individuals in the painting with an appearance of Down syndrome. Several prior observers have identified Down syndrome in premodern art, sometimes stimulating ongoing discussions concerning its history, its prevalence, and its… 
On the Antiquity of Trisomy 21: Moving Towards a Quantitative Diagnosis of Down Syndrome in Historic Material Culture
TLDR
The history of the understanding of Down syndrome is discussed, both skeletal remains and different forms of material culture that may depict Down syndrome are described, and where relevant, debates within the literature about how likely such qualitative diagnoses are to be correct are discussed.
The 50th anniversary of the discovery of trisomy 21: The past, present, and future of research and treatment of Down syndrome
TLDR
Different Trisomy 21 research groups have already identified candidate genes that are potentially involved in the formation of specific Down syndrome features, and these advances in turn may help to develop targeted medical treatments for persons with Trisome 21.
Down Syndrome: Current Status, Challenges and Future Perspectives
TLDR
More recent progress has resulted in the development of noninvasive prenatal screening (NIPS) test using cell-free fetal DNA sequences isolated from a maternal blood sample, and a review on those achievements is discussed.
Triple X syndrome: a review of the literature
TLDR
Research on triple X syndrome may yield more insight into brain and behaviour relations, developmental psychopathology, auditory-processing disorders, EEG disorders, personality and psychotic disorders, etc.
From the Genesis of Down syndrome: What we know and what we still need toknow
TLDR
This review suggests ways with the invention of technology how this anomaly can be treated immediately after the diagnosis of trisomy 21, as there's still a lot to do on the prognosis.
Hemidystonia – hemiatrophy syndrome in Domenico Morone's Madonna with child
  • D. Lippi, D. Lazzeri, W. R. Albury, G. Weisz
  • Medicine
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2016
TLDR
An image of the Madonna and Child painted by one of the less well-known Italian artists of the Renaissance raises the question of whether his obvious physical deformities were deliberately portrayed as an empathic gesture toward children with disabilities.
Genetics and genomics of Down syndrome
TLDR
It is illustrated how recent genomic science may be useful in the elucidation of the genotype-phenotype relationship in DS.
Genetics in the art and art in genetics.
TLDR
Some 'gestalt' Genetic Syndrome Diagnostic algorithms are applied to virtual patients found in some art masterpieces and in some the diagnosis is clear and in others the artists' depiction only supports a speculative differential diagnosis.
Risk factors for Down syndrome
  • F. Coppedè
  • Biology, Medicine
    Archives of Toxicology
  • 2016
TLDR
This article critically reviews the hypotheses and the risk factors which have been suggested to contribute to the birth of a child with DS, including folate metabolism, dietary, lifestyle, environmental, occupational, genetic and epigenetic factors, taking into account the possible contribution of the maternal grandmother and that of the developing trisomic embryo.
Diagnostic Pediatric Hematopathology: Hematologic abnormalities in individuals with Down syndrome
TLDR
This chapter will use the term hematologic abnormalities in the newborn with DS (HANDS) to refer to the hematological abnormalities associated with DS.
...
1
2
3
...

References

SHOWING 1-10 OF 26 REFERENCES
Is Down Syndrome A Modern Disease?
  • E. Volpe
  • Medicine
    Perspectives in biology and medicine
  • 1986
TLDR
Down syndrome is the most common congenital disorder associated with severe mental retardation and was the first human developmental anomaly to be traced to an alteration in the chromosome complement—namely,trisomy of chromosome 21 or, simply, trisomy 21.
Comparison of mental development in individuals with mosaic and trisomy 21 Down's syndrome.
TLDR
Since present psychological assessment techniques do not permit reaching valid conclusions about the ultimate intellectual status in very young infants with Down's syndrome, physicians and other professionals need to be careful when recommending early placement outside the home based merely upon the diagnosis.
Genetics and Malformations in Art
This attractively presented book, hardback, which has been prepared "for parents and all those who care for children with cystic fibrosis", contains clear clinical descriptions of the disease,
CRETIN OR MONGOL, OR BOTH TOGETHER
A painting of extraordinary pediatric interest hangs in the Boston Museum of Fine Arts, a Madonna and Child by Andrea Mantegna (1431-1506), who helped link the mystical middle ages with the mate
One face of beauty, one picture of health: the hidden aesthetic of medical practice.
TLDR
It is suggested that there is an important and as yet unrecognized role played by visual and perceptual preferences in the authors' judgments concerning normalcy and anomaly, and a shift away from the current fashion-magazine, youth-oriented aesthetic, and towards an aesthetic of imperfection.
A History of the Care and Study of the Mentally Retarded.
TLDR
The author deals with a wide range of issues including the development of humanitarian concern for the mentally subnormal, the emergence of institutional care in Europe and America, the origins of differential diagnosis and nosology, the rise of the eugenics movement, the growth of organizations and periodicals concerned with mental subnormality, and the new opportunities for prevention, treatment, and research which derive from recent genetic and metabolic studies.
The Gheel experience. Eternal spirit of the chainless mind!
TLDR
In light of a development that can be regarded as progressive, it may be useful to outline the experience of the release of state mental hospital patients to communities not prepared to receive them.
Relationship of autoimmunity to thyroid dysfunction in children and adults with Down syndrome.
TLDR
Thyroid dysfunction in individuals with DS of all ages is a common heterogeneous disorder which cannot be solely explained on the basis of autoimmunity and it is recommended that thyroid function be followed closely whether or not thyroid autoantibodies are present.
On Monsters and Marvels
TLDR
Pare's book on monsters, which stems from the late 16th century, is now available to English readers and contains many strange animals once deemed quite marvellous—rhinoceros, whale, giraffe, and toucan, among others—as well as some mythological creatures.
A History of Mental Retardation
TLDR
It's not surprisingly when entering this site to get the book, the popular book now is the the history of mental retardation, and searching for this popular book in this website will give you benefit.
...
1
2
3
...