An ancient family of SelB elongation factor-like proteins with a broad but disjunct distribution across archaea

@inproceedings{Atkinson2010AnAF,
  title={An ancient family of SelB elongation factor-like proteins with a broad but disjunct distribution across archaea},
  author={Gemma C. Atkinson and Vasili Hauryliuk and Tanel Tenson},
  booktitle={BMC Evolutionary Biology},
  year={2010}
}
SelB is the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome. In archaea, only a subset of methanogens utilizes selenocysteine and encodes archaeal SelB (aSelB). A SelB-like (aSelBL) homolog has previously been identified in an archaeon that does not encode selenosysteine, and has been proposed to be a pyrrolysyl-tRNA-specific elongation factor (EF-Pyl). However, elongation factor EF-Tu is capable of binding archaeal Pyl-tRNA in bacteria, suggesting the archaeal… CONTINUE READING