An anatomically comprehensive atlas of the adult human brain transcriptome

  title={An anatomically comprehensive atlas of the adult human brain transcriptome},
  author={Michael J. Hawrylycz and Ed S. Lein and Angie Guillozet‐Bongaarts and Elaine H. Shen and Lydia Ng and Jeremy A. Miller and Louie N. van de Lagemaat and Kimberly A. Smith and Amanda J. Ebbert and Zackery L. Riley and Chris Abajian and Christian F. Beckmann and Amy Bernard and Darren Bertagnolli and Andrew F. Boe and Preston M. Cartagena and M. Mallar Chakravarty and Mike Chapin and Jimmy Chong and Rachel Dalley and Barry David Daly and Chinh Dang and Suvro Sankha Datta and Nick Dee and Tim Dolbeare and Vance Faber and David Feng and David R. Fowler and Jeff Goldy and Benjamin W. Gregor and Zeb Haradon and David R. Haynor and John G. Hohmann and Steve Horvath and Robert E. Howard and A. Jeromin and Jayson M. Jochim and Marty Kinnunen and Christopher Lau and Evan T. Lazarz and Changkyu Lee and Tracy A. Lemon and Lingling Li and Yang Li and J. Morris and Caroline C. Overly and Patrick D. Parker and Sheana E. Parry and Melissa Reding and Joshua J. Royall and Jay Schulkin and P. Adolfo Sequeira and Cliff Slaughterbeck and Simon C. Smith and Andrew Sodt and Susan M. Sunkin and Beryl E. Swanson and Marquis P. Vawter and Derric Williams and Paul E. Wohnoutka and Horst Ronald Zielke and Daniel H. Geschwind and Patrick R. Hof and Stephen M. Smith and Christof Koch and Seth G. N. Grant and Allan R. Jones},
Neuroanatomically precise, genome-wide maps of transcript distributions are critical resources to complement genomic sequence data and to correlate functional and genetic brain architecture. Here we describe the generation and analysis of a transcriptional atlas of the adult human brain, comprising extensive histological analysis and comprehensive microarray profiling of ∼900 neuroanatomically precise subdivisions in two individuals. Transcriptional regulation varies enormously by anatomical… 

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