An analytical framework in the general coalescent tree setting for analyzing polymorphisms created by two mutations.

@article{Sargsyan2015AnAF,
  title={An analytical framework in the general coalescent tree setting for analyzing polymorphisms created by two mutations.},
  author={Ori Sargsyan},
  journal={Journal of mathematical biology},
  year={2015},
  volume={70 4},
  pages={913-56}
}
This paper presents an analytical framework for analyzing polymorphisms created by two mutation events in samples of DNA sequences modeled in the general coalescent tree setting. I developed the framework by deriving analytical formulas for the numbers of the topologies of the genealogies with two mutation events. This approach gives an advantage to analyze polymorphisms in large samples of DNA sequences at a non-recombining locus under vicarious evolutionary scenarios. Particularly the… CONTINUE READING

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