An analytic solution to single nucleotide polymorphism error-detection rates in nuclear families: implications for study design.

@article{Gordon2000AnAS,
  title={An analytic solution to single nucleotide polymorphism error-detection rates in nuclear families: implications for study design.},
  author={Derek Gordon and Simone Leal and S. C. Heath and J{\"u}rg Ott},
  journal={Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing},
  year={2000},
  pages={
          663-74
        }
}
Recently, there has been increased interest in using Single Nucleotide Polymorphisms (SNPs) as a method for detecting genes for complex traits. SNPs are diallelic markers that have the potential to be inexpensively produced using chip technology. It has been suggested that SNPs will be beneficial in study designs that utilize trio data (father, mother, child). In our previous work, we calculated the probability of detecting Mendelian errors at a SNP locus for a trio randomly selected from a… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

References

Publications referenced by this paper.
Showing 1-2 of 2 references

Error-Detection Rate for quartets as function of allele frequency and true error rate Pacific

  • S. C. Heath, Am J Hum Genet
  • Pacific Symposium on Biocomputing
  • 2000

J

  • D. Gordon, T. C. Matise, S. C. Heath
  • Ott, Genet Epidemiol (in press) (Dec
  • 1999

Similar Papers

Loading similar papers…