An analysis of tumor necrosis factor α gene polymorphisms and haplotypes with natural clearance of hepatitis C virus infection

@article{Thio2004AnAO,
  title={An analysis of tumor necrosis factor α gene polymorphisms and haplotypes with natural clearance of hepatitis C virus infection},
  author={Chloe L. Thio and James Jerome Goedert and Tim Mosbruger and David Vlahov and Steffanie Anne Strathdee and Stephen J. O'Brien and Jacquie Astemborski and David L Thomas},
  journal={Genes and Immunity},
  year={2004},
  volume={5},
  pages={294-300}
}
The cytokine tumor necrosis factor alpha (TNF-α) is important in generating an immune response against a hepatitis C virus (HCV) infection. The functions of TNF-α may be altered by single-nucleotide polymorphisms (SNPs) in its gene, TNF. We hypothesized that SNPs in TNF may be important in determining the outcome of an HCV infection. To test this hypothesis, we typed nine TNF SNPs in a cohort of individuals with well-defined HCV outcomes. Three of these SNPs were typed in a second cohort. Data… CONTINUE READING
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