An analysis of the sensitivity and specificity of the cytokeratin marker CAM 5.2 for epithelial tumours. Results of a study of 203 sarcomas, 50 carcinomas and 28 malignant melanomas

@article{Leader1986AnAO,
  title={An analysis of the sensitivity and specificity of the cytokeratin marker CAM 5.2 for epithelial tumours. Results of a study of 203 sarcomas, 50 carcinomas and 28 malignant melanomas},
  author={Mary B Leader and Jay Patel and Carol A. Makin and Kristin Henry},
  journal={Histopathology},
  year={1986},
  volume={10}
}
Two hundred and three sarcomas, 40 carcinomas, 10 carcinomas with spindle cell features, 27 malignant melanomas and one spindle cell melanoma were examined using CAM 5.2, a monoclonal antibody to cytokeratin. This antibody which was prepared against colorectal carcinoma cells and which identifies low molecular weight intermediate filament cytokeratin proteins is suitable for use in formalin fixed, paraffin embedded material. Seventeen of the 203 sarcomas showed positive staining. These included… 
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TLDR
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Utility of Immunohistochemistry in Separating Thymic Neoplasms From Germ Cell Tumors and Metastatic Lung Cancer Involving the Anterior Mediastinum
TLDR
An IHC panel consisting of CD5, CK5/6, PLAP, TTF-1, and CD57 is useful for the separation of thymic neoplasms from other epithelial malignancies involving the mediastinum.
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TLDR
A study of 127 cases confirms the expression of low molecular weight cytokeratins in intraepithelial neoplasia of grade CIN III or greater in cervical biopsies and compares the use of three monoclonal antibodies in demonstrating the phenomenon.
Cytokeratin immunoreactivity in gliomas
TLDR
The immunostaining of astrocytomas and oligodendrogliomas with AE1/3 might represent co‐expression of cytokeratin with glial fibrillary acidic protein by gliomas and calls for caution in the use of these antibodies in the differential diagnosis between glioma and carcinomas.
Comparison of commercially available cytokeratin antibodies in normal and neoplastic adult epithelial and non-epithelial tissues.
TLDR
Five commercially available cytokeratin antibodies were used to stain a wide range of normal and neoplastic epithelial and non-epithelial tissues to assess their potential value in diagnostic histopathology, and all showed good specificity, with some cross-reactivity in smooth muscle cells.
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