An analysis of the mechanisms involved in the okadaic acid-induced contraction of the estrogen-primed rat uterus.

@article{Arteche1997AnAO,
  title={An analysis of the mechanisms involved in the okadaic acid-induced contraction of the estrogen-primed rat uterus.},
  author={E Arteche and Giovanni F M Strippoli and Gervaise Loirand and Pierre Pacaud and Luz Candenas and Juan Carlos Molt{\'o} and Lu{\'i}s Ricardo Martinh{\~a}o Souto and Jacquelina Fern{\'a}ndez and Manuel Norte and Julio D. Mart{\'i}n and J. P. Savineau},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1997},
  volume={282 1},
  pages={201-7}
}
The contractile effect of okadaic acid (OA) and its derivatives was investigated in the rat uterus. OA (20 microM) induced a transient contraction which, after plateauing, slowly decreased. The structurally related compound okadanol (20 microM) failed to induce any significant contraction. Conversely, the synthetic compound methyl okadaate (20 microM) and the naturally occurring ester 7'-hydroxy-4'-methyl-2'-methylen-hept-4'(E)-enyl okadaate (20 microM) were as active as the free acid. The OA… CONTINUE READING
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