An analysis of the mechanism of local anesthetic inhibition of platelet aggregation and secretion.

@article{Feinstein1976AnAO,
  title={An analysis of the mechanism of local anesthetic inhibition of platelet aggregation and secretion.},
  author={Moshe Feinstein and Jerome F. Fiekers and C Fraser},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1976},
  volume={197 1},
  pages={
          215-28
        }
}
Aggregation induced in human platelets by thrombin (TH), collagen (COLL) or the Ca++ ionophore, A23187, was blocked by dibucaine and tetracaine. COLL-induced aggregation was blocked at lower concentrations of anesthetics (0.01-0.5 mM) than TH- or A23187-induced aggregation (0.2-2.0 mM). The rate and magnitude of the release of adenosine diphosphate, Ca++ and serotonin was also decreased by anesthetics. Secretion due to COLL, but not to TH, required extracellular Ca++ and was accompanied by… CONTINUE READING

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„Alternative“ Effekte von Lokalanästhetika

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