An analysis of the factors allowing promotion (rather than inhibition) of tumour growth by Corynebacterium parvum.

@article{Bomford1977AnAO,
  title={An analysis of the factors allowing promotion (rather than inhibition) of tumour growth by Corynebacterium parvum.},
  author={R H Bomford},
  journal={International journal of cancer},
  year={1977},
  volume={19 5},
  pages={673-9}
}
  • R H Bomford
  • Published 1977 in International journal of cancer
The following factors were found to determine whether C. parvum (CP) treatment promoted rather than inhibited the growth of methylcholanthrene-induced fibrosarcoma cells injected into CBA mice. (1) The dose of tumour cells. Promotion occurred only with low doses, around the TD50. (2) The route of injection of CP. Greater promotion was caused by intravenous (IV) than by subcutaneous (SC) administration. Addition of irradiated tumour cells to SC CP resulted in tumour inhibition. (3) The dose of… CONTINUE READING