An analysis of the early events when oligodendrocyte precursor cells are triggered to differentiate by thyroid hormone, retinoic acid, or PDGF withdrawal.

@article{Tokumoto1999AnAO,
  title={An analysis of the early events when oligodendrocyte precursor cells are triggered to differentiate by thyroid hormone, retinoic acid, or PDGF withdrawal.},
  author={Yasuhito M. Tokumoto and B{\'e}atrice Durand and Martin C. Raff},
  journal={Developmental biology},
  year={1999},
  volume={213 2},
  pages={
          327-39
        }
}
Oligodendrocyte precursor cells withdraw from the cell cycle and terminally differentiate after a limited number of cell divisions. The timing of cell-cycle withdrawal and differentiation is controlled by an intrinsic timer, which consists of a timing component that measures elapsed time and an effector component that arrests the cell cycle and initiates differentiation. The effector component can be triggered by either thyroid hormone (TH) or retinoic acid (RA). In this study we investigate… CONTINUE READING
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