An analysis of synaptic transmission to motoneurones in the cat spinal cord using a new selective receptor blocker.

@article{Engberg1993AnAO,
  title={An analysis of synaptic transmission to motoneurones in the cat spinal cord using a new selective receptor blocker.},
  author={Ingemar Engberg and Istv{\'a}n Tarnawa and Jacques Durand and Mustapha Ouardouz},
  journal={Acta physiologica Scandinavica},
  year={1993},
  volume={148 2},
  pages={97-100}
}
We have investigated the role of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors on synaptic transmission in vivo between Ia primary afferents and cat spinal motoneurones using a selective non-N-methyl-D-aspartate (non-NMDA) receptor antagonist, GYKI 52466. Both microionophoretic and intravenous application of GYKI 52466 depressed the excitatory post-synaptic potential (Ia EPSP) in a dose-dependent manner, without any apparent effect on membrane conductance or resting… CONTINUE READING