An analysis of in vitro T cell responsiveness in lepromatous leprosy

  title={An analysis of in vitro T cell responsiveness in lepromatous leprosy},
  author={Gilla Kaplan and David E. Weinstein and Ralph Marvin Steinman and William R. Levis and U Elvers and Manuel Elkin Patarroyo and Zanvil Alexander Cohn},
  journal={The Journal of Experimental Medicine},
  pages={917 - 929}
In lepromatous leprosy, there is extensive replication of Mycobacterium leprae (M. leprae) within dermal macrophages. This lack of microbial resistance has been attributed to a defective cell-mediated immune response to M. leprae antigens. We have examined the in vitro response of T cells to M. leprae to determine if hyporesponsiveness could be reversed. The study included 40 unselected patients from New York and from Colombia, most with the severe lepromatous form of the disease. We first… CONTINUE READING
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