An analogue of piperonyl butoxide facilitates the characterisation of metabolic resistance.

  title={An analogue of piperonyl butoxide facilitates the characterisation of metabolic resistance.},
  author={Graham D. Moores and Despina Philippou and Valerio Borzatta and Paolo Trincia and Philip J Jewess and Robin V. Gunning and Georgina V. Bingham},
  journal={Pest management science},
  volume={65 2},
BACKGROUND Previous work has demonstrated that piperonyl butoxide (PBO) not only inhibits microsomal oxidases but also resistance-associated esterases. The ability to inhibit both major metabolic resistance enzymes makes it an ideal synergist to enhance xenobiotics but negates the ability to differentiate which enzyme group is responsible for conferring resistance. RESULTS This study examines an analogue that retains the ability to inhibit esterases but is restricted in its ability to act on… CONTINUE READING

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