An analog of the natural steroidal alkaloid cortistatin A potently suppresses Tat-dependent HIV transcription.

@article{Mousseau2012AnAO,
  title={An analog of the natural steroidal alkaloid cortistatin A potently suppresses Tat-dependent HIV transcription.},
  author={Guillaume Mousseau and Mark A. Clementz and Wendy Bakeman and Nisha Nagarsheth and Michael Cameron and Jun Shi and Phil S Baran and R{\'e}mi Fromentin and Nicolas Chomont and Susana T. Valente},
  journal={Cell host & microbe},
  year={2012},
  volume={12 1},
  pages={97-108}
}
The human immunodeficiency virus type 1 (HIV) Tat protein, a potent activator of HIV gene expression, is essential for integrated viral genome expression and represents a potential antiviral target. Tat binds the 5'-terminal region of HIV mRNA's stem-bulge-loop structure, the transactivation-responsive (TAR) element, to activate transcription. We find that didehydro-Cortistatin A (dCA), an analog of a natural steroidal alkaloid from a marine sponge, inhibits Tat-mediated transactivation of the… CONTINUE READING
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