An amplified sensitivity arising from covalent modification in biological systems.

@article{Goldbeter1981AnAS,
  title={An amplified sensitivity arising from covalent modification in biological systems.},
  author={Albert Goldbeter and Daniel E. Koshland},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1981},
  volume={78 11},
  pages={6840-4}
}
The transient and steady-state behavior of a reversible covalent modification system is examined. When the modifying enzymes operate outside the region of first-order kinetics, small percentage changes in the concentration of the effector controlling either of the modifying enzymes can give much larger percentage changes in the amount of modified protein. This amplification of the response to a stimulus can provide additional sensitivity in biological control, equivalent to that of allosteric… CONTINUE READING
Highly Influential
This paper has highly influenced 63 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS