An amphipathic alpha-helical decapeptide in phosphatidylcholine is an effective synthetic lung surfactant.

@article{McLean1993AnAA,
  title={An amphipathic alpha-helical decapeptide in phosphatidylcholine is an effective synthetic lung surfactant.},
  author={Larry R. McLean and John E. Lewis and John L Krstenansky and Karen A. Hagaman and A S Cope and Karl F. Olsen and E Matthews and Dennis C. Uhrhammer and Thomas J. Owen and Marguerite H. Payne},
  journal={The American review of respiratory disease},
  year={1993},
  volume={147 2},
  pages={
          462-5
        }
}
An idealized model amphipathic alpha-helical decapeptide was synthesized and tested for efficacy as a totally synthetic lung surfactant in simple mixtures with dipalmitoylphosphatidylcholine (DPPC). Quasi-static lung compliance was restored to 92 +/- 3% of the unlavaged value at a pressure of 5 cm H2O in an in vitro lavaged rat lung model. A sustained improvement in gas exchange was also observed when guinea pigs were treated with the synthetic lung surfactant in an in vivo lavaged lung model… 
Protein-phospholipid interactions in pulmonary surfactant. The Parker B. Francis Lectureship.
TLDR
Simplified peptide analogues of SP-B, dispersed in DPPC and POPG, provide strong surfactant activity in vitro and in the lungs of premature infant rabbits, rhesus monkeys, and humans.
Primary importance of zwitterionic over anionic phospholipids in the surface-active function of calf lung surfactant extract.
TLDR
Measurements of surface properties in vitro and pressure-volume mechanics in excised rat lungs in situ suggest that zwitterionic phospholipids have a major role over anionic phosphate in interacting with hydrophobic SP in the adsorption, dynamic surface tension lowering, film respreading, and pulmonary mechanical activity of thehydrophobic components of calf lung surfactant in CLSE.
Synthetic Surfactant Protein Analogues
TLDR
The inferior in vivo activity of synthetic surfactants containing SP-C only compared to that of surfactant preparations derived from natural sources may be caused by a lack of covalently linked palmitoyl groups in the analogues and/or absence of SP-B.
New Synthetic Surfactants – Basic Science
TLDR
The lipid composition seems to be important, as well as a high lipid concentration in the suspension, for successful treatment of many respiratory diseases, it is also desirable that the synthetic surfactant resists inactivation by plasma components leaking into the alveoli.
Artificial surfactants based on analogues of SP-B and SP-C.
TLDR
The development of synthetic analogues of the surfacant proteins might make it possible to tailor artificial surfactants for specific therapeutic missions, for instance by enhancing resistance to inactivation by meconium, plasma proteins, or oxygen radicals or maximizing bacteriostatic effects.
Efficacy of Synthetic Peptide-Containing Surfactant in the Treatment of Respiratory Distress Syndrome in Preterm Infant Rhesus Monkeys
TLDR
The importance of the peptide in the synthetic surfactant was apparent, and animals treated with a dose of 200 mg/kg showed a faster, more consistent, and greater response than did a group treated with an average dose of 127mg/kg.
ARTIFICIAL SURFACTANTS BASED ON ANALOGUES OF SP-B AND SP-C
TLDR
The development of synthetic analogues of the surfactant proteins might make it possible to tailor artificial surfactants for specific therapeutic missions, for instance by enhancing resistance to inactivation by meconium, plasma proteins, or oxygen radicals or maximizing bacteriostatic effects.
The pproteins oof tthe ssurfactant ssystem
TLDR
It is speculated that, in the near future, surfactant preparations based on recombinant hydrophobic proteins will be available for clinical use, and in babies with respiratory distress syndrome, the clinical response to treatment with surfACTant containing SP-B and SP-C is much faster than in babies treated with protein-free synthetic surfactants.
Molecular structures and interactions of pulmonary surfactant components.
The dominating functional property of pulmonary surfactant is to reduce the surface tension at the alveolar air/liquid interface, and thereby prevent the lungs from collapsing at the end of
...
...

References

SHOWING 1-10 OF 15 REFERENCES
Minimal peptide length for interaction of amphipathic alpha-helical peptides with phosphatidylcholine liposomes.
TLDR
The interactions of a series of amphipathic alpha-helical peptides containing from 6 to 18 amino acid residues with dipalmitoylphosphatidylcholine and DPPC were studied by optical and calorimetric methods and formed small micellar structures, as judged by gel filtration chromatography.
Synthetic amphipathic sequences of surfactant protein-B mimic several physicochemical and in vivo properties of native pulmonary surfactant proteins.
A mixture of lipids and proteins unique to the lung lines the airspaces of all mammalian species. This mixture, termed pulmonary surfactant, is essential for normal lung function. We have synthesized
The Use of Synthetic Peptides in the Formation of Biophysically and Biologically Active Pulmonary Surfactants
TLDR
The data demonstrate that several peptides matching the carboxy-terminal sequence of the SP-B protein, when appropriately recombined with the phospholipids dipalmitoylphosphatidycholine and phosphatidylglycerol, are capable of producing a synthetic surfactant with biophysical and biologic activity approaching that of human Surfactant derived from amniotic fluid.
Pulmonary surfactant protein B (SP-B): structure-function relationships.
TLDR
These data, together with findings that the SP-B-related peptides increase inter- and intramolecular order of the phospholipid layer, suggest thatSP-B resists surface tension by increasing lateral stability of the phosphate layer.
Restoration of Lung Pressure-Volume Characteristics with Various Phospholipids
TLDR
The ability of certain phospholipids (PL), either singly or in combination, to restore the lung pressure-volume (PV) characteristics to normal was determined to provide a basis for development of a synthetic surfactant for treatment of respiratory distress syndrome (RDS).
Surface active materials from dog lung. II. Composition and physiological correlations.
TLDR
All four fractions exhibited the surface properties expected of pulmonary surfactant, as judged by their low surface tensions, quantitative spreading in the air-liquid interface, surface compressibilities, and adsorption kinetics.
...
...