An amperometric immunosensor for diagnosis of celiac disease based on covalent immobilization of open conformation tissue transglutaminase for determination of anti-tTG antibodies in human serum.

@article{Giannetto2014AnAI,
  title={An amperometric immunosensor for diagnosis of celiac disease based on covalent immobilization of open conformation tissue transglutaminase for determination of anti-tTG antibodies in human serum.},
  author={Marco Giannetto and Monica Mattarozzi and Eleonora Umilt{\`a} and Anita Manfredi and Sara Quaglia and Maria Careri},
  journal={Biosensors & bioelectronics},
  year={2014},
  volume={62},
  pages={325-30}
}
A new amperometric immunosensor based on the covalent immobilization of tissue transglutaminase enzyme in its open conformation (open-tTG) was developed and optimized for determination of anti-tissue transglutaminase antibodies (anti-tTG) in human serum. Experimental design allowed us to find the optimal conditions for quantification of both IgA and IgG isotypes of anti-tTG in order to assess suitability of the device for diagnostic purposes. The glassy carbon electrodic substrate was… CONTINUE READING
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