An aminotransferase branch point connects purine catabolism to amino acid recycling.

@article{Ramazzina2010AnAB,
  title={An aminotransferase branch point connects purine catabolism to amino acid recycling.},
  author={Ileana Ramazzina and R. Costa and L. Cendron and R. Berni and A. Peracchi and G. Zanotti and R. Percudani},
  journal={Nature chemical biology},
  year={2010},
  volume={6 11},
  pages={
          801-6
        }
}
Although amino acids are known precursors of purines, a pathway for the direct recycling of amino acids from purines has never been described at the molecular level. We provide NMR and crystallographic evidence that the PucG protein from Bacillus subtilis catalyzes the transamination between an unstable intermediate ((S)-ureidoglycine) and the end product of purine catabolism (glyoxylate) to yield oxalurate and glycine. This activity enables soil and gut bacteria to use the animal purine waste… Expand
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