An amino-terminal fragment of lac repressor binds specifically to lac operator.

@article{Ogata1978AnAF,
  title={An amino-terminal fragment of lac repressor binds specifically to lac operator.},
  author={Ronald T. Ogata and Walter Gilbert},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1978},
  volume={75 12},
  pages={5851-4}
}
We have examined the effect of an aminoterminal peptide from the lac repressor (residues 1-59) on the methylation of purines in the lac operator with dimethyl sulfate. The peptide perturbs the methylation of the operator, and the peptide-induced pattern of inhibition and enhancement of methylation, across the operator, closely resembles the pattern induced by intact repressor. This demonstrates that this small amino-terminal peptide binds specifically to the lac operator and that the mechanism… CONTINUE READING

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