An amino-terminal fragment of hemokinin-1 has an inhibitory effect on pruritic processing in rats.


Hemokinin-1 (HK-1) is a peptide encoded by the preprotachykinin gene, TAC-4, and shares the hydrophobic carboxyl-terminal (C-terminal) region common to mammalian tachykinin peptides, such as substance P (SP). It is generally believed that C-terminal fragments of SP elicit an excitatory effect, while pretreatment with amino-terminal (N-terminal) fragments of… (More)
DOI: 10.1016/j.neuroscience.2013.10.070


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