An amino-acid taste receptor

  title={An amino-acid taste receptor},
  author={Greg Nelson and Jayaram Chandrashekar and Mark A. Hoon and Luxin Feng and Grace Q. Zhao and Nicholas J. P. Ryba and Charles S Zuker},
The sense of taste provides animals with valuable information about the nature and quality of food. Mammals can recognize and respond to a diverse repertoire of chemical entities, including sugars, salts, acids and a wide range of toxic substances. Several amino acids taste sweet or delicious (umami) to humans, and are attractive to rodents and other animals. This is noteworthy because l-amino acids function as the building blocks of proteins, as biosynthetic precursors of many biologically… 

L-Amino Acids Elicit Diverse Response Patterns in Taste Sensory Cells: A Role for Multiple Receptors

Calcium imaging of isolated taste sensory cells and taste cell clusters from the circumvallate and foliate papillae of C57BL/6J and T1r3 knockout mice indicated that synergistic and non-synergistic responses to L-amino acids and IMP are mediated by multiple receptors or possibly a receptor complex.

Pharmacology of the Umami Taste Receptor.

Activation of T1R1/T1R3 by all known umami substances evaluated and the receptor's pharmacological properties are sufficient to explain the basic human sensory experience of savory taste and it is therefore unlikely that other receptors are involved.

Receptors for the detection of L-amino acids and IMP by mouse taste sensory cells

The data indicate that synergistic and non-synergistic responses to L-amino acids and IMP are mediated by multiple receptors or possibly a receptor complex.

Taste, Chemical Biology of

Evidence is accumulating to show that taste receptor and signal transduction molecules have nongustatory functions as well, and the extragustatory expression of such genes and the resulting implications are summarized in the final section.

Genetics of Amino Acid Taste and Appetite.

Overall, mouse strain differences in amino acid taste and appetite have a complex genetic architecture and the identification of these genes may lead to the discovery of novel mechanisms that regulate amino acid Taste and appetite.

The receptors and coding logic for bitter taste

It is demonstrated, using a combination of genetic, behavioural and physiological studies, that T2R receptors are necessary and sufficient for the detection and perception of bitter compounds, and that differences in T2Rs between species can determine the selectivity of bitter taste responses.

Evolution of the primate glutamate taste sensor from a nucleotide sensor

Involvement of the Calcium-sensing Receptor in Human Taste Perception

This is the first report indicating a distinct function of the CaSR in human taste perception, and a large number of CaSR agonist γ-glutamyl peptides, including GSH (γ-Glu-Cys-Gly), are identified and it is demonstrated that these peptides elicit the kokumi taste.

Taste receptors for umami: the case for multiple receptors.

This work has shown that the responses to umami tastants persist in the taste cells of T1R3-knockout mice, suggesting that umami taste detection may involve multiple receptors expressed in different subsets of taste cells.



A family of candidate taste receptors in human and mouse

The identification of a family of candidate taste receptors (the TRBs) that are members of the G-protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells are reported.

A metabotropic glutamate receptor variant functions as a taste receptor

A GPCR cloned from rat taste buds and functionally expressed in CHO cells is described, which shows an unusual concentration–response relationship and the similarity of its properties to MSG taste suggests that this receptor is a taste receptor for glutamate.

A candidate taste receptor gene near a sweet taste locus

A candidate taste receptor gene, T1r3, is described that is located at or near the mouse Sac locus, a genetic locus that controls the detection of certain sweet tastants.

Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac

A likely candidate is identified: T1R3, a previously unknown G protein-coupled receptor (GPCR) and the only GPCR in this region of the sequenced human genome syntenous to the region of Sac in mouse, which is the major determinant of differences between sweet-sensitive and -insensitive strains of mice in their responsiveness to saccharin, sucrose and other sweeteners.

Identification of a novel member of the T1R family of putative taste receptors

T1R3 maps near the telomere of mouse chromosome’4 rendering it a candidate for the Sac locus, a primary determinant of sweet preference in mice, and displays taste receptor cell‐specific expression.

Taste reception.

Taste transduction typically utilizes two or more pathways in parallel, and to identify these pathways, to understand how they are controlled and why they evolved to this complexity are major goals of present research.