An amino-acid taste receptor

@article{Nelson2002AnAT,
  title={An amino-acid taste receptor},
  author={Greg Nelson and Jayaram Chandrashekar and Mark A. Hoon and Luxin Feng and Grace Q. Zhao and Nicholas J. P. Ryba and Charles S. Zuker},
  journal={Nature},
  year={2002},
  volume={416},
  pages={199-202}
}
The sense of taste provides animals with valuable information about the nature and quality of food. Mammals can recognize and respond to a diverse repertoire of chemical entities, including sugars, salts, acids and a wide range of toxic substances. Several amino acids taste sweet or delicious (umami) to humans, and are attractive to rodents and other animals. This is noteworthy because l-amino acids function as the building blocks of proteins, as biosynthetic precursors of many biologically… 
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TLDR
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TLDR
This is the first report indicating a distinct function of the CaSR in human taste perception, and a large number of CaSR agonist γ-glutamyl peptides, including GSH (γ-Glu-Cys-Gly), are identified and it is demonstrated that these peptides elicit the kokumi taste.
Taste receptors for umami: the case for multiple receptors.
TLDR
This work has shown that the responses to umami tastants persist in the taste cells of T1R3-knockout mice, suggesting that umami taste detection may involve multiple receptors expressed in different subsets of taste cells.
The Receptors for Mammalian Sweet and Umami Taste
TLDR
It is demonstrated that sweet and umami taste are strictly dependent on T1R-receptors, and it is shown that selective elimination of T 1R-subunits differentially abolishes detection and perception of these two taste modalities.
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