An amino acid position at crossroads of evolution of protein function: antibiotic sensor domain of BlaR1 protein from Staphylococcus aureus versus clasS D β-lactamases.

@article{Kumarasiri2012AnAA,
  title={An amino acid position at crossroads of evolution of protein function: antibiotic sensor domain of BlaR1 protein from Staphylococcus aureus versus clasS D β-lactamases.},
  author={Malika Kumarasiri and Leticia I. Llarrull and Oleg Ya Borbulevych and Jennifer Fishovitz and Elena Lastochkin and Brian M. Baker and Shahriar Mobashery},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 11},
  pages={8232-41}
}
The integral membrane protein BlaR1 of Staphylococcus aureus senses the presence of β-lactam antibiotics in the milieu and transduces the information to its cytoplasmic side, where its activity unleashes the expression of a set of genes, including that for BlaR1 itself, which manifest the antibiotic-resistant phenotype. The x-ray structure of the sensor… CONTINUE READING