An alternatively spliced cyclin D1 isoform, cyclin D1b, is a nuclear oncogene.

@article{Lu2003AnAS,
  title={An alternatively spliced cyclin D1 isoform, cyclin D1b, is a nuclear oncogene.},
  author={Fengmin Lu and Andrew B Gladden and J Alan Diehl},
  journal={Cancer research},
  year={2003},
  volume={63 21},
  pages={7056-61}
}
Glycogen synthase kinase-3beta-dependent phosphorylation of cyclin D1 at a conserved COOH-terminal residue, Thr-286, promotes CRM1-dependent cyclin D1 nuclear export at the G(1)-S boundary. Mutations that perturb the phosphorylation of cyclin D1 at Thr-286 contribute to cell transformation, although to date, no such mutations have been found in human cancers. Cyclin D1 (CCND1) undergoes alternative splicing leading to the production of an mRNA predicted to encode a unique cyclin D1 isoform… CONTINUE READING
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