An alternative view of the role(s) of surfactant and the alveolar model.

@article{Hills1999AnAV,
  title={An alternative view of the role(s) of surfactant and the alveolar model.},
  author={Brian Andrew Hills},
  journal={Journal of applied physiology},
  year={1999},
  volume={87 5},
  pages={
          1567-83
        }
}
  • B. Hills
  • Published 1 November 1999
  • Biology
  • Journal of applied physiology
Currently, the study of surfactant proteins is much in vogue, but, in the early days, the physics underlying surfactant function was treated somewhat superficially, leaving assumptions that have become culturally embedded, such as the "bubble" model of the alveolus. This review selectively reexamines these assumptions, comparing each combination of alveolar model and role of surfactant for compatibility with the major features of pulmonary mechanics and alveolar stability, morphology, and fluid… 
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91 Citations

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Opposing views on the alveolar surface, alveolar models, and the role of surfactant.
Emile M. Scarpelli: There is a body of work that relates directly and specifically to the review article of Dr. Hills, “An alternative view of the role(s) of surfactant and the alveolar model,” which…
More Anatomically Realistic and Quantitative Models of Pulmonary Surfactant Action and Alveolar Stability
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Development of the concept of a liquid pulmonary alveolar lining layer.
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The widespread persistence of the notion that the pulmonary alveoli are normally lined with liquid is referred to, which persists in the scienti®c community in the face of a simple law of physics that shows it to be impossible.
Thin liquid films as a model to study surfactant layers on the alveolar surface
Pulmonary mechanics and gas exchange: a mathematical framework
PULMONARY ALVEOLUS ' MODEL INCLUDING SURFACE TENSION EFFECTS
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Mechanical models are developed, based on the finite element method, taking into account fluid droplets in alveolar corners and their surface tension, capable to represent the collapse and the sudden opening of an alveolus.
Structure-function relationships in pulmonary surfactant membranes: from biophysics to therapy.
Alveolar mechanics in the acutely injured lung: role of alveolar instability in the pathogenesis of ventilator-induced lung injury.
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Alveolar histophysiology is researched with animal experiments that combined a conventional histological approach with in vivo microscopy to assess alveolar dynamics during normal and disease-state ventilation and indicates that the various behaviors reportedly exhibited by alveoli may be consistent and represent a continuum between normal alveolars function and thealveolar mechanics of acute lung injury.
Asthma: surfactant eliminates the early allergen-induced response
  • B. Hills
  • Physics
    European Respiratory Journal
  • 2004
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In interpreting these impressive results, however, the authors invoke theory based upon oedema at whose liquid-air interface surfactant could exert a “high surface pressure”, which appears to have ignored a basic principle of surface physics.
Agreement in surfactant measurements of sputum induced with hypertonic and normal saline
TLDR
The level of DPPC in induced sputum obtained using hypertonic saline is examined and compared with that obtained using normal saline to assess airway cells and mediators.
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  • B. Hills
  • Medicine
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  • 1994
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