An alternative to the LTP orthodoxy: a plasticity-pathology continuum model

  title={An alternative to the LTP orthodoxy: a plasticity-pathology continuum model},
  author={J. McEachern and C. Shaw},
  journal={Brain Research Reviews},
  • J. McEachern, C. Shaw
  • Published 1996
  • Biology, Medicine
  • Brain Research Reviews
  • Long-term potentiation (LTP) is probably the most widely studied form of synaptic plasticity in the mammalian central nervous system. In the early descriptions, the term referred to a sustained increase in synaptic response following a brief high-frequency electrical tetanus. Apparently unique properties of the phenomenon triggered considerable excitement in the field: for many, LTP offered the promise of a potential substrate for learning and/or memory. In the more than 20 years since LTP was… CONTINUE READING
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    Publications referenced by this paper.
    Synaptic plasticity in the hippocampus: LTP and LTD
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