An alternative telomerase RNA in Arabidopsis modulates enzyme activity in response to DNA damage.

@article{CifuentesRojas2012AnAT,
  title={An alternative telomerase RNA in Arabidopsis modulates enzyme activity in response to DNA damage.},
  author={Catherine Cifuentes-Rojas and Andrew D. L. Nelson and Kara A. Boltz and Kalpana Kannan and Xintao She and Dorothy E Shippen},
  journal={Genes & development},
  year={2012},
  volume={26 22},
  pages={2512-23}
}
Telomerase replenishes telomere tracts by reiteratively copying its RNA template, TER. Unlike other model organisms, Arabidopsis thaliana harbors two divergent TER genes. However, only TER1 is required for telomere maintenance. Here we examine the function of TER2. We show that TER2 is spliced and its 3' end is truncated in vivo to generate a third TER isoform, TER2(S). TERT preferentially associates with TER2 > TER1 > TER2(S). Moreover, TER2 and TER2(S) assemble with Ku and POT1b (protection… CONTINUE READING
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