An alternative stochastic model of generation of oligodendrocytes in cell culture.

@article{Boucher2001AnAS,
  title={An alternative stochastic model of generation of oligodendrocytes in cell culture.},
  author={Kenneth M. Boucher and Andrey Zorin and Andrei Y Yakovlev and Margot Mayer-Proschel and Mark Noble},
  journal={Journal of mathematical biology},
  year={2001},
  volume={43 1},
  pages={22-36}
}
According to our previous model, oligodendrocyte--type 2 (O-2A) astrocyte progenitor cells become competent for differentiation in vitro after they complete a certain number of critical mitotic cycles. After attaining the competency to differentiate, progenitor cells divide with fixed probability p in subsequent cycles. The number of critical cycles is random; analysis of data suggests that it varies from zero to two. The present paper presents an alternative model in which there are no… CONTINUE READING

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