An alternative splicing event which occurs in mouse pachytene spermatocytes generates a form of DNA ligase III with distinct biochemical properties that may function in meiotic recombination.

@article{Mackey1997AnAS,
  title={An alternative splicing event which occurs in mouse pachytene spermatocytes generates a form of DNA ligase III with distinct biochemical properties that may function in meiotic recombination.},
  author={Zachary B. Mackey and William Rodr{\'i}guez Ramos and David S. Levin and Christi A Walter and John Robert McCarrey and Alan E Tomkinson},
  journal={Molecular and cellular biology},
  year={1997},
  volume={17 2},
  pages={
          989-98
        }
}
Three mammalian genes encoding DNA ligases have been identified. However, the role of each of these enzymes in mammalian DNA metabolism has not been established. In this study, we show that two forms of mammalian DNA ligase III, alpha and beta, are produced by a conserved tissue-specific alternative splicing mechanism involving exons encoding the C termini of the polypeptides. DNA ligase III-alpha cDNA, which encodes a 103-kDa polypeptide, is expressed in all tissues and cells, whereas DNA… CONTINUE READING
BETA

Citations

Publications citing this paper.

Similar Papers

Loading similar papers…