An alternative route to cyclic terpenes by reductive cyclization in iridoid biosynthesis

@article{GeuFlores2012AnAR,
  title={An alternative route to cyclic terpenes by reductive cyclization in iridoid biosynthesis},
  author={Fernando Geu-Flores and Nathaniel H. Sherden and Vincent Courdavault and Vincent Burlat and Weslee S Glenn and Cen Wu and Ezekiel Nims and Yuehua Cui and Sarah E. O’Connor},
  journal={Nature},
  year={2012},
  volume={492},
  pages={138-142}
}
The iridoids comprise a large family of distinctive bicyclic monoterpenes that possess a wide range of pharmacological activities, including anticancer, anti-inflammatory, antifungal and antibacterial activities. Additionally, certain iridoids are used as sex pheromones in agriculturally important species of aphids, a fact that has underpinned innovative and integrated pest management strategies. To harness the biotechnological potential of this natural product class, the enzymes involved in… 

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