An alternative route for the folding of large RNAs: apparent two-state folding by a group II intron ribozyme.

@article{Su2003AnAR,
  title={An alternative route for the folding of large RNAs: apparent two-state folding by a group II intron ribozyme.},
  author={Linhui Julie Su and M. Brenowitz and Anna M Pyle},
  journal={Journal of molecular biology},
  year={2003},
  volume={334 4},
  pages={639-52}
}
Despite a growing literature on the folding of RNA, our understanding of tertiary folding in large RNAs derives from studies on a small set of molecular examples, with primary focus on group I introns and RNase P RNA. To broaden the scope of RNA folding models and to better understand group II intron function, we have examined the tertiary folding of a ribozyme (D135) that is derived from the self-splicing ai5gamma intron from yeast mitochondria. The D135 ribozyme folds homogeneously and… CONTINUE READING

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Single-molecule studies of group II intron ribozymes.

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