An alternative role of C1q in cell migration and tissue remodeling: contribution to trophoblast invasion and placental development.

@article{Agostinis2010AnAR,
  title={An alternative role of C1q in cell migration and tissue remodeling: contribution to trophoblast invasion and placental development.},
  author={Chiara Agostinis and Roberta Bulla and Claudio Tripodo and Angela Angela Gismondi and Helena Stabile and Fleur Bossi and Carla Guarnotta and Cecilia Garlanda and Francesco de Seta and Paola Spessotto and Angela Santoni and Berhane Ghebrehiwet and Guillermina Girardi and Francesco Saverio Tedesco},
  journal={Journal of immunology},
  year={2010},
  volume={185 7},
  pages={4420-9}
}
Fetal trophoblast cells invading the decidua in the early phase of pregnancy establish complex interaction with the maternal extracellular matrix. We discovered that C1q was widely distributed in human decidual stroma in the absence of C4 and C3 and was actively synthesized by migrating extravillous trophoblasts. The cells expressed the messages for the three chains of C1q and secreted this complement component that interacted with the proteins of the decidual extracellular matrix. Solid phase… CONTINUE READING
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