An alternative role for Foxp3 as an effector T cell regulator controlled through CD40.

@article{Vaitaitis2013AnAR,
  title={An alternative role for Foxp3 as an effector T cell regulator controlled through CD40.},
  author={Gisela M. Vaitaitis and Jessica R. Carter and Dan M. Waid and Michael H. Olmstead and David H Wagner},
  journal={Journal of immunology},
  year={2013},
  volume={191 2},
  pages={717-25}
}
The BDC2.5 T cell clone is highly diabetogenic, but the transgenic mouse generated from that clone is surprisingly slow in diabetes development. Although defining pathogenic effector T cells in autoimmunity has been inconsistent, CD4(+) cells expressing the CD40 receptor (Th40 cells) are highly diabetogenic in NOD mice, and NOD.BDC2.5.TCR.Tg mice possess large numbers of these cells. Given the importance of CD40 for pathogenic T cell development, BDC2.5.CD40(-/-) mice were created. Regulatory T… CONTINUE READING
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The Expanding Role of TNF-Receptor Super Family Member CD40 (tnfrsf5) in Autoimmune Disease: Focus on Th40 Cells

  • G. Vaitaitis, D. M. Waid, D. Wagner, Jr.
  • Curr. Immunol. Rev
  • 2010
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