An alternative pathway of imiquimod-induced psoriasis-like skin inflammation in the absence of interleukin-17 receptor a signaling.

@article{Malki2013AnAP,
  title={An alternative pathway of imiquimod-induced psoriasis-like skin inflammation in the absence of interleukin-17 receptor a signaling.},
  author={Khalifa El Malki and Susanne H. Karbach and Jula Huppert and Morad Zayoud and Sonja Reissig and Rebecca Sch{\"u}ler and Alexej Nikolaev and Khalad Karram and Thomas F. M{\"u}nzel and Christoph Ruediger Wolfram Kuhlmann and Heiko J. Luhmann and Esther von Stebut and Simone Woertge and Florian C Kurschus and Ari Waisman},
  journal={The Journal of investigative dermatology},
  year={2013},
  volume={133 2},
  pages={441-51}
}
Topical application of imiquimod (IMQ) on the skin of mice induces inflammation with common features found in psoriatic skin. Recently, it was postulated that IL-17 has an important role both in psoriasis and in the IMQ model. To further investigate the impact of IL-17RA signaling in psoriasis, we generated IL-17 receptor A (IL-17RA)-deficient mice (IL-17RA(del)) and challenged these mice with IMQ. Interestingly, the disease was only partially reduced and delayed but not abolished when compared… CONTINUE READING