An alternative pathway for Alu retrotransposition suggests a role in DNA double-strand break repair.

@article{Srikanta2009AnAP,
  title={An alternative pathway for Alu retrotransposition suggests a role in DNA double-strand break repair.},
  author={Deepa Srikanta and Shurjo K Sen and Charles T. L. Huang and Erin M Conlin and Ryan M Rhodes and Mark A. Batzer},
  journal={Genomics},
  year={2009},
  volume={93 3},
  pages={205-12}
}
The Alu family is a highly successful group of non-LTR retrotransposons ubiquitously found in primate genomes. Similar to the L1 retrotransposon family, Alu elements integrate primarily through an endonuclease-dependent mechanism termed target site-primed reverse transcription (TPRT). Recent studies have suggested that, in addition to TPRT, L1 elements occasionally utilize an alternative endonuclease-independent pathway for genomic integration. To determine whether an analogous mechanism exists… CONTINUE READING
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