An alternative exon 1 of the CD5 gene regulates CD5 expression in human B lymphocytes.

@article{Renaudineau2005AnAE,
  title={An alternative exon 1 of the CD5 gene regulates CD5 expression in human B lymphocytes.},
  author={Yves Renaudineau and Sophie Hillion and Alain Saraux and Rizgar A Mageed and Pierre Youinou},
  journal={Blood},
  year={2005},
  volume={106 8},
  pages={2781-9}
}
T lymphocytes and a subpopulation of B lymphocytes express the CD5 coreceptor. Its functional importance is evident from the multiple levels and developmental stages of the regulation of its expression. We here report the discovery of a novel regulatory exon upstream of the noncoding region of the CD5 gene in humans. This alternate exon 1 is designated E1B (with the conventional exon 1 renamed E1A) and was shown to regulate the expression of CD5. E1B-containing transcripts existed exclusively… CONTINUE READING

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