An alternative concept for the molecular nature of the peroxidating ability of anthracycline anti-tumor antibiotics and anthracenodiones.

Abstract

Quantum chemical calculations of model anthraquinone molecules using the CNDO/2 method have revealed that superoxide anion radical formation following the single electron transfer mediated by anthraquinone anti-tumor antibiotics may occur in aerobic conditions as a result of the direct addition of an electron to the anthraquinone-oxygen low energy charge… (More)

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