An altered Mycobacterium tuberculosis metabolome induced by katG mutations resulting in isoniazid resistance.

  • Du Toit Loots
  • Published 2014 in Antimicrobial agents and chemotherapy

Abstract

The most common form of drug resistance found in tuberculosis (TB)-positive clinical samples is monoresistance to isoniazid. Various genomics and proteomics studies to date have investigated this phenomenon; however, the exact mechanisms relating to how this occurs, as well as the implications of this on the TB-causing organisms function and structure, are… (More)
DOI: 10.1128/AAC.02344-13

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