An alpha-subunit-secreting cell line derived from a mouse thyrotrope tumor.

@article{Akerblom1990AnAC,
  title={An alpha-subunit-secreting cell line derived from a mouse thyrotrope tumor.},
  author={Ingrid Akerblom and Eli Chester Ridgway and Pamela L Mellon},
  journal={Molecular endocrinology},
  year={1990},
  volume={4 4},
  pages={589-96}
}
The anterior pituitary contains multiple distinct endocrine cell types that secrete individual hormones. To derive a pure cell culture population in which to study the regulation of the alpha-subunit of TSH free of other hormones and cell types, we have developed a clonal continuous cell line from the transplantable thyrotrope tumor MGH101A. This cell line expresses alpha-subunit mRNA, secretes alpha-subunit protein, and has maintained a stable phenotype for over 3 yr in culture. However, as is… CONTINUE READING