An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective.

@article{Wang1996AnAA,
  title={An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective.},
  author={Kenneth Kezhi Wang and R Nath and A. Posner and Kadee J. Raser and M Buroker-Kilgore and Iradj Hajimohammadreza and A WProbert and Frank Marcoux and Qing Ye and Emiko Takano and Minoru Hatanaka and Masatoshi Maki and Hakan Caner and Jennifer L Collins and Andrea Fergus and Ki Seog Lee and Elizabeth A. Lunney and Sheryl J. Hays and Po-wai Yuen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 13},
  pages={6687-92}
}
Overactivation of calcium-activated neutral protease (calpain) has been implicated in the pathophysiology of several degenerative conditions, including stroke, myocardial ischemia, neuromuscular degeneration, and cataract formation. Alpha-mercaptoacrylate derivatives (exemplified by PD150606), with potent and selective inhibitory actions against calpain, have been identified. PD150606 exhibits the following characteristics: (i) Ki values for mu- and m-calpains of 0.21 microM and 0.37 microM… CONTINUE READING
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Wang et al

  • H. Kishimoto, J. R. Simon, +4 authors Student’s t-test. 6692 Neurobiology
  • Proc. Natl. Acad. Sci. USA 93
  • 1996
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