• DOI:10.1038/s41586-019-1094-6
Corpus ID: 93000843

An allosteric mechanism for potent inhibition of human ATP-citrate lyase

@article{Wei2019AnAM,
  title={An allosteric mechanism for potent inhibition of human ATP-citrate lyase},
  author={Jia Wei and S. Leit and Jun Kuai and Eric Therrien and Salma Rafi and H. J. Harwood and B. DeLaBarre and L. Tong},
  journal={Nature},
  year={2019},
  volume={568},
  pages={566-570}
}

Jia Wei, S. Leit, +5 authors L. Tong

Published 2019

Chemistry, Medicine

Nature

ATP-citrate lyase (ACLY) is a central metabolic enzyme and catalyses the ATP-dependent conversion of citrate and coenzyme A (CoA) to oxaloacetate and acetyl-CoA1–5. The acetyl-CoA product is crucial for the metabolism of fatty acids6,7, the biosynthesis of cholesterol8, and the acetylation and prenylation of proteins9,10. There has been considerable interest in ACLY as a target for anti-cancer drugs, because many cancer cells depend on its activity for proliferation2,5,11. ACLY is also a target… CONTINUE READING

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